Harmatoma - benign tumor composed of tissue elements found at site but disorganized
Benign
- hepatic adenoma
- histologically no portal structure but with normal liver apperance
- ~ 20 cm well circumscribed nodules, predisposed to increased estrogen
- bile duct adenoma
- small white nodules beneath liver capsule
- abnormal "bile duct" in a collagenous stroma
- hemangioma
- beneath capsule as a dark/black lesion 2~3 cm
- histologically abnormal "vascular channels" in a collagenous stroma
Malignancy
- metastatic tumor (lung, colon, breast, stomach), malignant lymphomas, leukemias
=> accumulation of tumor deposits can lead to compression of intrahepatic bile duct and lead to obstructive jaundice
- primary hepatocellular carcinoma (hepatoma)
risks - cirrhosis, HBV, mycotoxins
Serum Alpha-fetoproteins may be raised
- cholangiocarcinoma
- due to chronic inflammatory disease of intra-hepatic biliary tree
- angiosarcoma
- multifocal hemorrhagic nodules
